منابع مشابه
Nicorandil: the drug that keeps on giving.
Nicorandil is a nicotinamide nitrate used as an antianginal agent. It has two modes of action. First, by opening adenosine triphosphate–dependent potassium channels, nicorandil increases transmembrane potassium conductance and relaxes peripheral and coronary arterioles. Second, with its nitrate moiety, nicorandil increases intracellular concentrations of cGMP, resulting in peripheral vein and c...
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In cyanobacteria, the RbcX protein enhances the production of Rubisco, the multisubunit enzyme that catalyzes the first step of carbon dioxide fixation in most autotrophic organisms. In this issue of Cell, Saschenbrecker et al. (2007) report that RbcX acts as a specific assembly chaperone that mobilizes the large subunits of Rubisco to a specific oligomeric core that can then combine with the s...
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Case 1: A 39-year-old man with chronic lower extremity lymphedema was admitted to the hospital with acute fever, chills, and left lower extremity pain, swelling, and erythema for the third time in as many months. Examination revealed a temperature of 39 degrees C (102.2 degrees F), and erythmatous induration on the left leg (Figure). The patient was treated with IV clindamycin and cefazolin, wi...
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914 November 2014 T HE pulmonary circulation is distinct from the systemic circulation both in structure and in function. Pharmacologic options for selective therapeutic manipulation of pulmonary vascular tone are limited. A major clinical milestone in contemporary perioperative practice has been the advent of selective pulmonary vasodilators that have transformed the management of pulmonary hy...
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Stents are now used routinely for catheter-based coronary revascularization procedures. Early clinical trials of stents demonstrated reduced rates of angiographic restenosis compared with balloon angioplasty alone.1–3 In a registry analysis of 1403 patients, 64% of whom were treated with stents, the need for repeat revascularization was 39% less than in a similar cohort having coronary interven...
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ژورنال
عنوان ژورنال: Blood
سال: 2019
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.2019002284